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Although surgery is not always necessary, when appropriate, the primary surgeries involved in treating orthopedic complications of neurofibromatosis Type 1 include: Bone grafting with an intramedullary rod for pseudarthrosis, where an intramedullary rod is placed inside the bone to promote healing

4 Research progress of the serine synthesis pathway in pan-cancer The transcriptional expression differences of key enzymes in the de novo serine synthesis pathway (including PHGDH, PSAT1 and PSPH) across pan-cancer specimens were systematically analyzed using the Timer online database ( Figure 2 ), revealing the expression heterogeneity and potential tumor-specific expression patterns of these enzymes in distinct cancer types

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