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As a sensitivity analysis, we additionally compared53 cases of patients with proven ALD to MASLD, the effect size was highest for 3-hydroxybutyrate (OR: 1.76, 95%CI 1.44-2.15, p=4,01E-08) and acetoacetate (OR:1.66, 95%1.35-2.06, p=2,2E-06), followed by large HDL related markers.To prove that the lipidomic signature is stable over time, we repeated the analyses comparing MetALD vs

Olive oil phenolic extract regulates interleukin-8 expression by transcriptional and posttranscriptional mechanisms in Caco-2 cells

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Although initially activated to buffer metabolic stress, the PINK1-Parkin pathway becomes suppressed under chronic overload, such as prolonged palmitate exposure, resulting in dysfunctional mitochondria, heightened oxidative stress, and activation of the NLRP3 inflammasome