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These results directly confirm that excessive NNMT activation suppresses NAD+ synthesis and impairs energy metabolism, while NNMT inhibition effectively reverses this process, establishing NNMT as a negative regulator of energy metabolism

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ClinicalTrials.gov lists 3 ongoing or completed trials (accessed February 12, 2026): NCT05239615 (topical for photoaging, Phase II, completed 2024, no results posted) [12]

It is involved in the regeneration of vitamin C from its oxidized form and performs important protective functions at the level of the cell membrane and in the multiple enzymatic systems in which it is involved