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These studies indicate that overproduction of glutathione drives the survival and growth of a small subset of lymphoid tumor cells in 3D gels and xenografts, likely TIC or TIC-like cells, and that glutathione is selectively required for tumor growth in females of a mouse model of lymphoma

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2.6 Ultra-high-performance liquid chromatographyhigh-resolution mass spectrometry analysis 2.6.1 UHPLC conditions Samples were evaluated with a Vanquish ultra-high-performance liquid chromatographyhigh-resolution mass spectrometry (UHPLC) system manufactured by Thermo Fisher Scientific, Germany, connected to an ACQUITY UPLC HSS T3 column with dimensions of 2.1 mm 100 mm and a particle size of 1.8 m