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Another meta-analysis of 9 randomized controlled trials (RCTs) with 486 patients who compared the vitamin E group with the control group showed a beneficial effect of vitamin E on the incidence and symptoms of CIPN but also proposed that routine prophylactic use of vitamin E is still not recommended [78]

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Those warnings include thyroid tumor risk and MEN2 contraindications

Many reported skin reactions have been temporary (i.e., lasting several minutes), although some cases resulted in treatment discontinuation (Madsen, F1000Res 2019)