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Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output, Cell, 183 (2020) 769322

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The principal function attributed to ICP34.5 involves enhancing viral propagation across peripheral tissues alongside central nervous systems, contributing significantly toward HSV, and inducing neurovirulence via various mechanisms including protein phosphatase I (PPI) dephosphorylating eIF2, thus preventing shutoff from host protein synthesis while enabling continuous production (11, 30, 31)