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According to the 2019 definition of Stage B1, the heart either has no enlargement OR either the left atrium (LA) OR the left ventricle (LV) is enlarged, but not both of them, OR, if both of them are enlarged, one of both of them are not enlarged up to the minimum dimensions of the 2019 version of Stage B2

Destabilizing the tear film will result in the development of DED if any LFU component is damaged, as well as if neural and endocrine disorders (such as sensory and motor nerve dysfunction, or hormonal imbalance) arise [3]