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During ageing, mtDNA, Tfam, ROS, ATP, cardiolipin, and N-formyl peptide can be released as DAMPs and are recognized by pattern recognition receptors upon mitochondrial stress or compromise, leading to the activation of MiDAS and SASP

The combination stability assay of PBA-COS conjugate at different time points

Lack of Akt activation in these cells suggests that a lack of pro-survival pathways may contribute to the increased rates of cell death and apoptosis in GPx-1-deficient cells

The images were acquired using magnetization-prepared 2 rapid acquisition gradient echo (MP2RAGE, research prototype sequence) [41] with the following parameters: TR, 6000 ms