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doi: 10.1182/blood-2004-10-4094 17 FrascaLFedeleGDeaglioSCapuanoCPalazzoRVaisittiTet al

Semaglutide (the GLP-1 half of CagriSema) and tirzepatide both agonize it, which is why both suppress appetite, slow gastric emptying, and improve glycemic measures

however, this does not require phosphorylation of PDE3B on S273 by AKT2 (117)

[1] [4] Healthcare providers should consider alternative therapies with established safety profiles in pregnant or lactating patients whenever possible, and if glutathione injection is deemed necessary, close monitoring of both mother and child is recommended throughout treatment