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Journal of Biological Chemistry 277, 3945639462.CrossRefGoogle ScholarPubMed Dong, C et al

This enhancement is achieved through several mechanisms, including the inhibition of various drug metabolism enzymes (e.g., CYP1A1, -1B1, -1B2, -2E1, -3A4) and P-gp, as well as by stimulating amino acid transporters and decreasing glucuronic acid production

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After that, at 70% cell confluence, the medium was replaced with another medium containing 50 g/mL of RhB-labeled blank and DTX-loaded NPs at 37 C for 0.5 and 3 h incubation to treatment 35