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The activation of AMPK broadly suppresses proinflammatory signaling pathways, including the JAK-STAT, NF-B, C/EBP, CHOP, and HIF-1 pathways, which in turn inhibits the expansion and immunosuppressive function of myeloid-derived suppressor cells (MDSCs) 42

XSJ improves CDAHFD-induced liver fibrosis by inhibiting the activity of the TGF-1/Smads and PI3K/AKT/Hmox1 signaling pathways To validate the results of the transcriptomic analysis, we performed RT-qPCR to verify the selected DEGs

We express our gratitude to Pengfei Gong, Ruipei Ouyang, and Yongjie Shi from Jiangsu Province Engineering Research Center of Synthetic Peptide Drug Discovery and Evaluation, China Pharmaceutical University , for helping revise the manuscript

Kwon HS, Koh SH