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Altenhfer S, Radermacher KA, Kleikers PW, Wingler K, Schmidt HH (2015) Evolution of NADPH oxidase inhibitors: selectivity and mechanisms for target engagement

Cancers 12(9):19

Correlations between TYR, TRP, and some purines may originate in the diet or other common organism-wide influences, but some of these appear to be lost as these compounds undergo further transformations along their respective pathways

However, it is important to emphasize that cells can carry out a premature mitotic exit known as mitotic slippage, which is the major mechanism of rescue cells from MTAs, limiting the therapeutic efficacy of these drugs [79]