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Baseline measurements should confirm AMPK suppression (reduced phosphorylation status in muscle or liver) and NAD+ depletion (low tissue NAD+ levels or elevated NNMT enzymatic activity)

Repeat to desired dosage or as directed by a healthcare provider

People who notice progressive hollowing of the mid-face, reduced definition along the jawline, or generalized skin laxity that isnt responding to topical interventions tend to see better outcomes with GH-releasing peptides like Tesamorelin than with surface-level aesthetics alone

Some patients pursuing both aesthetic and recovery goals are evaluated for combined protocols, but the choice always follows a clinical assessment rather than a fixed bundle