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Children with NF1 often have cognitive and learning disabilities and an increased incidence of autism, cardiac abnormalities and seizures, says Dr

Simultaneously, the AECs transition from a productive differentiation/growth state to a highly localized translational/signaling phenotype in old age, a functional change that could provide the cellular explanation for the active vascular and immune interactions observed in the bulk profile, driven by a stressed or senescent secretory response in the aged endothelium

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Along with consideration of the patients clinical status, measuring procalcitonin levels may help guide antibiotic therapy decisions in patients with community-acquired pneumonia (Pinzone 2014