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The expression of immediate early genes such as c-fos is decreased in the hippocampus after acute alcohol intoxication ( It is also known that alcohol potentiates GABA inhibition and inhibits glutamate excitation in the hippocampal brain regions indicating these molecular entities are potential mechanistic mediators for acute alcohol-induced cognitive impairment

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Recently, the structure of the ghrelin receptor bound to an antagonist compound 21 revealed a characteristic feature that the binding pocket is bifurcated into two cavities by a salt bridge between E124 3.33 and R283 6.55 18