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degenerate codon substitutions may be achieved by generating sequences in which the third position of one or more selected (or all) codons is nucleic acid is used interchangeably with gene, cDNA, and mRNA encoded by a gene

They are necessary for regulating critical biochemical processes such as Ca 2+ storage and homeostasis, activation of the oxidative stress response, and cell death pathways (Ribas et al., 2014)