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How long before a competition do I need to stop using marijuana or cannabinoids

In the SURMOUNT-1 trial, participants lost up to 22.5% of body weight over 72 weeks (study on tirzepatide in obesity)

A 2018 Cell Metabolism follow-up found that under metabolic stress, MOTS-c actually moves into the nucleus and helps regulate gene expression there, tying it into stress-response pathways (PMID 29983246) [4]