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Moreover, an ineffective activity of Gly II might also entrap GSH thereby resulting in S -lactoylglutathione accumulation, which is highly cytotoxic 33

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When started, PI3K converts phosphatidylinositol 4,5-bisphosphate (PIP2) to phosphatidylinositol 3,4,5-trisphosphate (PIP3), which recruits Akt to the plasma membrane where it becomes started through phosphorylation