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Shoulders on the main peak or unexpected peaks at 30-60% of the main peak retention time suggest truncated sequences (deletion products from failed couplings) that often retain partial activity and confound pharmacological interpretation

Participants with renal impairment were excluded if they had previously undergone renal transplantation or had unstable renal function or acute exacerbation of renal disease within 14 days of baseline, as indicated by recent history or worsening of clinical or laboratory signs

Data availability Atomic coordinates and structure factors for the crystal structures of the TRF1 TRFH domain in complex with the compounds discussed herein have been deposited in the Protein Data Bank (www.wwpdb.org) and can be accessed using the PDB accession numbers provided in Supplementary Table 3

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