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The applications in gene knockdown and overexpression experiments in K-562 cells dramatically enhanced the extent of gene alteration, with the gene knockdown efficiency increasing from 7% to 60% and the gene overexpression level rising from 47 to 253 times

10.1074/jbc.M805905200 275 VillalbaM.HottM.MartinC.AguilaB.ValdiviaS.QuezadaC.et al

, NLR family pyrin domain containing 3 (NLRP3)) that sense pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs), such as the accumulation of ROS or the efflux of potassium ions (K + )