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Still, some early clinical findings hint at potential uses in more specific contexts: Perioperative brain protection: A randomized controlled trial involving 155 liver surgery patients found that ALA reduced oxidative brain injury from anesthesia (sevoflurane) and improved cognitive recovery scores after surgery.31 Neurodegenerative conditions: In a small trial, ALA appeared to slow brain atrophy in patients with secondary progressive multiple sclerosis over a two-year period.32 While promising, this outcome still needs further confirmation

In vitro study of -synuclein protofibrils by Cryo-EM suggests a Cu2+-dependent aggregation pathway

Butelli E, Licciardello C, Zhang Y, Liu J, Mackay S, Bailey P, Reforgiato Recupero G, Martin C: Retrotransposons control fruit-specific, cold-dependent accumulation of anthocyanins in blood oranges