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The association between hypophosphatemia and better clinical outcomes seems to be secondary to enhanced cell regeneration with hepatocyte phosphate uptake from the serum to generate ATP.39,40 Given the importance of serum phosphate levels, members of the Acute Liver Failure Study Group (commonly referred to as ASFLG) have included serum phosphate levels in their prognostic scoring system for mortality related to APAP hepatotoxicity.41 Age and genetic factors APAP, an analgesic utilized by patients from infancy into the geriatric years, shows age-related hepatotoxic tendencies

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