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In the tMCAO rat model, CHY improved neurological function and reduced infarct size by upregulating SLC7A11 and GPX4, and downregulating ferroptosis markers TfR1, PTGS2, and ACSL4, thereby lowering total iron, lipid peroxidation, and MDA levels, and mitigating oxidative stress

More importantly, IL-6 is a key marker of cellular aging, and the age-related strengthening of the IL-6 amplifier could be linked to COVID-19 mortality (Figure 6) (Murakami et al., 2019