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Metformin, an AMPK activator, inhibits TGF-1-induced myofibroblast differentiation by promoting AMPK expression, leading to myofibroblast deactivation and apoptosis, reduction in the expression of type I collagen, fibronectin (FN), and -SMA in fibroblasts, and downregulation of ECM protein levels, thereby slowing or reversing PF (Rangarajan et al., 2018)

Clinical signs of hepatic copper deposition : unexplained jaundice, hepatomegaly on exam, or new-onset ascites

However, assessing the environmental and safety impacts of metal-doped CDs-based nanozymes is also significant

doi: 10.1016/j.coi.2014.06.003 12 LewinsohnDALewinsohnDMScribaTJ