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Limited Human Very few human clinical trials exist, and those that do are generally small-scale, preliminary investigations

Chen YF, Liu H, Luo XJ, Zhao Z, Zou ZY, Li J, Lin XJ, Liang Y

doi: 10.1210/jc.2013-2218 100 RashidGKhanNAElsoriDYounessRAHassanHSiwanDet al

Compounds identified can be useful, for example, in modulating the activity of wild type and/or mutant MMP-29 polypeptide, preferably mutant MMP-29 polypeptide, can be useful in elaborating the biological function of the MMP-29 polypeptide, can be utilized in screens for identifying compounds that disrupt normal MMP-29 polypeptide interactions, or can in themselves disrupt such interactions