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Impaired oxidative phosphorylation (OXPHOS), elevated reactive oxygen species (ROS) levels, and calcium dysregulation disrupt cellular energetics and extracellular matrix (ECM) homeostasis, contributing to the hallmark features of hEDS

For example, degradation of bisphosphoglycerate mutase regulates acclimatization to high altitude hypoxia by constraining synthesis of 2,3-bisphosphoglycerate (Xu et al., 2022)an allosteric modulator of Hb that promotes oxygen off-loading in response to hypoxia (Webb et al., 2021)

Conventional drugs like metformin primarily exert their effects by improving IR, and studies have shown that they can modulate the gut microbiota, albeit with no significant impact on the levels of gut microbial metabolites ( in vitro fertilization demonstrated that berberine monotherapy was significantly superior to metformin monotherapy in improving live birth rate, reducing body mass index, decreasing follicle-stimulating hormone consumption, and enhancing gastrointestinal tolerability ( In the intervention of ferroptosis-related diseases, current therapeutic strategies face considerable challenges

Citations Citations to this article as recorded by Association of a body shape index (ABSI) with chronic kidney disease prevalence, all-cause and cardiovascular mortality: A 20-year prospective cohort study of 29,189 U.S