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In the SEV group, B12 increased SAH ( P = 0.0091) and reduced SAM/SAH ( P = 0.0021)

GST can be coupled to a glutathione matrix, which permits its use as an effective affinity column to study interactions in vitro or to purify protein complexes in cells expressing the GST-fusion protein

In addition, mutation or inactivation of the EZH2 gene in myelodysplastic syndrome [124] and T-cell acute lymphoblastic leukemia (T-ALL) [125], where its tumor suppressor role is strongly supported

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