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FIGURE 2 This oxidative stress environment can activate immune signalling pathways promoting neuroinflammation through mitochondrial dysfunction and impaired mitophagy, as observed in recent studies on ASD brains (Pinto Payares et al., 2024)

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For instance, Akkermansia muciniphila in the gut can induce immune homeostasis in mice, promote IgG production, and initiate antigen-specific T-cell responses, thereby improving symptoms of DSS-induced colitis (92)