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De Tullio et al., 2003

The release of proteases, including matrix metalloproteinases (MMPs), tissue proteases and neutrophil elastase, degrades the extracellular matrix and alveolar elastin, leading to localized and generalized alveolar emphysema (25)

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The review situates Dihexa within the renin-angiotensin systems central nervous system arm, summarizes the HGF/c-Met activation hypothesis, and surveys behavioral pharmacology in rodent cognitive models