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Vitamin B6 forms red blood cells, helps cells make protein, produces neurotransmitters, such as serotonin and releases stored forms of energy, helps prevent CVS disease and strokes, helps relieve depression, and alleviates insomnia

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Apatinib in combination with S-1 has shown promising efficacy and manageable toxicity as a second-line treatment for patients with GC, especially for elderly patients with poor performance status (108)