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In addition, a shift in the redox state increases the mRNA expression of HIF target genes, including glucose transporter type 1 (GLUT1), monocarboxylate transporter 4 (MCT4), and hexokinase 2 (HK2)

In extremely preterm infants, more than 50% of deaths also occur during the first 10 days of life 46,47 and preterm neonates may be most deficient in intestinal IGF-1 during the immediate postnatal period before endogenous IGF-1 production increases

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Dual mechanisms of posttranscriptional regulation of Tet2 by Let-7 microRNA in macrophages