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In this scenario, it becomes very attractive to study and explore the endothelium, through which inflammatory cells must transmigrate [transendothelial migration (TEM)] to reach the lung parenchyma and cause damage ultimately leading to COPD onset and progression

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Consequently, broad CAF-targeting therapies must be approached with caution, as removing all fibroblasts can inadvertently dampen immune surveillance, whereas targeting the right subtype can alleviate immunosuppression