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It is known that autophagy is defective in dopaminergic neurons in the SN, as observed in post-mortem brains of patients and certain models of PD like 6-OHDA and rotenone-induced models, which show suppression of mTOR, a key enhancer of autophagy (Grassi et al., 2018)

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For comparison, the human genome contains 48 ABC transporter genes including only two members of the MDR family (Dean and Annilo, 2005)

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