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However, it did not have therapeutic benefits in patients with Huntington disease (Dickey and La Spada, 2018)

vancomycin cuts serum acetate by 60% in mice) and deliverytargeted strategies (ex vivo T cell ACSS2 upregulation, pH-sensitive nanoparticles for tumor-specific release) are essential to avoid off-target effects (e.g., tumor lipid biosynthesis