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Comprehensive GSH Antioxidant Function Review (PubMed, 2023) GSH as the Central Non-Enzymatic Antioxidant in Mammalian Cells A comprehensive review of reduced glutathione (GSH) published on PubMed confirmed that GSH is an essential non-enzymatic antioxidant in mammalian cells that acts directly to protect cells against free radicals and pro-oxidants, and as a cofactor for antioxidant and detoxification enzymes including glutathione peroxidases, glutathione S-transferases, and glyoxalases

Targeted knockdown of polo-like kinase 1 alters metabolic regulation in melanoma

Selenium deficiency decreases the activity of selenoproteins, including glutathione peroxidases, which can lead to raised concentrations of hydrogen peroxide and thus promote inflammation and disease