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The World Mental Health (WMH) survey, using the WHO Composite International Diagnostic Interview (CIDI 3.0), identified BD as one of the most disabling psychiatric conditions, with affected individuals averaging 41.2 days of role impairment per year 36.5 of which were directly attributed to BD (Alonso et al., 2011)

Niyazov DM, Kahler SG, Frye R

These studies have also brought to light their potential as a rich and unexplored source for new therapeutic targets and agents through multiple avenues, including direct targeting of the catalytic sites, controlling disease-associated proteinprotein interactions and developing novel biologics from the secreted ARS proteins or their parts