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doi:10.1093/eurheartj/ehz455 Forte F, Calcaterra I, Lupoli R, et al

Furthermore, melatonin indirectly combats free radicals by chelating metal ions in the brain [148]

While stimulation of IGF-1R by IGFs triggers autophosphorylation and subsequent phosphorylation of either insulin receptor substrate-1 (IRS-1) or insulin receptor substrate-2 (IRS-2), it is clear that these adapter proteins are activated by both IR 15 and IGF-1R