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doi: 10.1016/j.clim.2023.109655 21 RatajczakWAtkinsonSDKellyC

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Upon activation, caspase-1 enzymatically processes the precursor pro-interleukin-1 (pro-IL-1) into its biologically active form, mature IL-1, which is then secreted into the extracellular milieu, triggering a robust inflammatory response ( Moreover, MSU triggers the release of pro-inflammatory cytokines, such as interleukin-6 (IL-6), through the NF-B and Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling cascades, consequently amplifying the infiltration of inflammatory cells ( Figure 1 )