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In the brain, reactive oxygen species (ROS) production is increased by IL-6 stimulation and mitochondrial cytochrome c oxidase is inhibited by nitric oxide, a potent inhibitor

Studies suggest that intraperitoneal injection of RES may inhibit the apoptotic Bax-caspase-3 pathway, thereby preventing RGC death

This suggests that the hair loss is not strictly dose-dependent in a linear way but rather connected to the metabolic changes that all therapeutic doses trigger, including significant weight loss with tirzepatide