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Importantly, glucose metabolism and insulin sensitivity were either unchanged or slightly improved, contrasting with the diabetogenic effects of growth hormone

Further in-depth pharmacokinetic studies on humans and toxicology research, the mechanism of combination therapy, and research on new CHE-based biomaterials for reducing drug toxicity and structurally optimized analogs are required to enhance the efficacy and safety of CHE, and more clinical studies are required in the future to validate preclinical studies of CHE as an antitumor strategy

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NAC is able to reduce cysteine conjugates and has the potential to act as an anticancer agent, however, caution should be paid since NAC has been reported to enhance the metastatic potential of melanoma cells in mice (Piskounova et al