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In addition, vitamin B12 is needed to produce myelin and is important for axon and nerve development

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In male rats at 250 and 500 mg/kg bw per day, increased incidences of mineral deposits in renal collecting ducts (31/50, 62%, and 20/50, 40%), tubular-cell hyperplasia (1/50, 2%, and 4/50, 8%), adenomas (0/50 and 2/50, 8%) and adenocarcinomas (3/50, 6%, and 1/50, 2%) were observed, but these were not found not in female rats (see Table 6)