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These results reveal the dynamic interplay between the structural states of the CRL4 DET1-COP1 E3 ligase complex and its substrate specific activation mechanism, offering mechanistic insights into ubiquitination regulation and a basis for future studies on E3 ligase dynamics

Neutralization stoichiometry Closely related to the mechanisms of antibody-mediated neutralization of viruses in vitro are the stoichiometry and kinetics of neutralization

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