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Furthermore, we found MANF promotes the transformation of mature hepatocytes into cholangiocyte-like cells in SBT and TAA-induced ICC by using the fluorescent reporter mice

The Journal of biological chemistry 264, 1544515450 pmid:2768271 61

Our extensive biochemical analyses of TGR combined with 3D structures of TGR complexes with various substrates, inhibitors, and in different redox states 17,30,31,32 , allow us to define in detail the catalytic mechanisms of TGR