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Abnormal lipid metabolism in cystathionine -synthase-deficient mice, an animal model for hyperhomocysteinemia

Upon erastin treatment, elevated lipid ROS production detected by flow cytometry using the fluorescent probe C 11 -BODIPY was observed in control cells, however, GSK-3 inhibition by LY remarkably reduced accumulation of lipid ROS in both HeLa and MDA-MB-231 cells, as well as Fer-1 treatment (Fig