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Physiological and pathological functions of NADPH oxidases during myocardial ischemiareperfusion

Elesclomol is widely recognized to induce copper overdose and cell death (139), by acting as a copper ion carrier with a hydrophilic pore in its centre, to which Cu2+ ions can bind easily, facilitating copper entry into cells, thus increasing the intracellular copper concentration (140), and this, in-turn increases ROS levels, triggering oxidative stress (141) and ultimately cell death

doi: 10.1038/s41467-019-08659-3 167 SilvaMVTDos SantosJCFigueiredoAMBTeufelLUPereiraJXMatosGGet al

Another study which investigated the changes in glutathione status after exercise used 2030 y men who cycled for 40 min at 60% of their maximal oxygen consumption in an attempt to determine the role of glutathione as determinants of lipid peroxidation