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CNB-CSIC has been designated Centre of Excellence Severo Ochoa and is funded by the Spanish Government through Grant SEV2017-0712

*Correspondence: Ken Takahashi [email protected] This article was submitted to Cardiovascular Metabolism, a section of the journal Frontiers in Cardiovascular Medicine Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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This interaction mediates the translocation of receptor-interacting protein kinase 1 (RIPK1) to the TNF receptor, forming a necrosome complex with RIPK3 and phosphorylating MLKL