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Scholler et al ., 2017

With anemia of inflammatory disease, the increased iron sequestered within macrophages may actually promote synthesis of ferroportin, which may partly offset the hepcidin- and other cytokine-mediated downregulation or degradation, allowing heme synthesis to continue and preventing a severe anemia in contrast to that seen with a true iron deficiency anemia

By overcoming limitations of conventional therapies, nanomedicines enable spatiotemporally controlled intervention through glycolysis inhibition, combinatorial metabolic-immune therapies, and the combination therapy of glucose metabolic with other treatment strategies, offering transformative potential for cancer treatment