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Cysteine, essential for GSH biosynthesis, and its oxidized form, cystine, are integral to this process, and impaired cysteine uptake or defective conversion to cysteine increases ferroptosis vulnerability [49]

Kizir D, Karaman M, Ceylan H (2023) Tannic acid may ameliorate doxorubicin-induced changes in oxidative stress parameters in rat spleen

However, current variants of roGFPs are largely inadequate in mutants with very low glutathione levels, generally oxidizing conditions like in the ER, or oxidizing conditions triggered by pathological processes

Rather than acting as mere providers of discrete nutrients or stress relievers, PGPR function by reprogramming the rhizosphere systemaltering its physicochemical niche, restructuring microbial community networks, and modulating plant physiologyto generate emergent properties that enhance overall system resilience and productivity