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9 Broadly, current pharmacologic treatment strategies include serotonin-norepinephrine reuptake inhibitors such as venlafaxine and duloxetine, tricyclic antidepressants, and the anticonvulsants gabapentin and pregabalin as first-line therapies

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Accumulating evidence has unveiled the bidirectional communication between gut microbiome and CNS, referred to as the microbiota-gut-brain axis (Forner et al., 2021