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1 Introduction DKD, characterized by persistent albuminuria and a progressive decline in the glomerular filtration rate among diabetic patients ( The hyperglycemic environment in diabetes triggers glomerular hyperfiltration and tubular epithelial damage ( Current therapeutic approaches for DKD primarily focus on the use of RAAS inhibitors and Sodium-Glucose Cotransporter 2 (SGLT-2) inhibitors, aimed at decelerating glomerular hyperfiltration and diminishing proteinuria ( In summary, the pathogenesis of DKD is complex, with the immune system playing a crucial role in its development

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A dulled needle causes more tissue damage, more pain, and creates a larger opening in the rubber stopper that accelerates coring

Jung, J